Medical Research Platform (MRP) is delighted to present a significant contribution to the field of infectious diseases with our latest research article titled “Clinical Manifestations of Monkeypox.” Authored by Haneen Abaza, Kuchalambal Agadi, Ayush Anand, and supervised by the esteemed Mohamed Elsaid, this comprehensive review sheds light on the various clinical manifestations of monkeypox. The findings of this study have been published as a chapter in the esteemed book, Advances in Experimental Medicine and Biology.
Study Leader/s
Study Supervisor
Members
Haneen Abaza
Kuchalambal Agadi
Ayush Anand
Mohamed Elsaid
ResearchGate link
Clinical Manifestations of Monkeypox
Book
Advances in Experimental Medicine and Biology
Introduction
Monkeypox is a significant global health concern caused by the monkeypox virus. Understanding the clinical manifestations of this infectious disease is crucial for accurate diagnosis, appropriate management, and prevention of further transmission. In this chapter, we aim to provide a comprehensive review of the clinical manifestations of monkeypox, highlighting the various symptoms and potential complications associated with this condition.
Methods
To compile this review, we conducted an extensive literature search using reputable databases such as PubMed and Google Scholar. We analyzed relevant studies, case reports, and clinical guidelines to gather a comprehensive understanding of the clinical manifestations of monkeypox. The information obtained was critically evaluated and synthesized to provide a comprehensive overview of the topic.
Clinical Manifestations
Monkeypox presents with a prodrome phase that lasts for a few days, characterized by non-specific symptoms such as fever, malaise, headache, and muscle aches. This is followed by the appearance of a rash, which is the hallmark of the disease. The dermatological manifestations of monkeypox progress through several stages, including macular, papular, and vesicular phases. The rash eventually crusts over and resolves within approximately three weeks.
In addition to the dermatological manifestations, patients with monkeypox may experience respiratory symptoms such as nasal congestion and shortness of breath. These respiratory symptoms can lead to secondary bacterial infections, which further complicate the clinical course of the disease.
Neurological involvement is another potential manifestation of monkeypox, with encephalitis being the most severe form. Ocular manifestations, including conjunctivitis, keratitis, and corneal ulceration, have also been reported in some cases.
Other symptoms that may accompany monkeypox include gastrointestinal symptoms such as diarrhea and vomiting, as well as myalgia and backache.
Diagnosis and Treatment
The gold standard for diagnosing monkeypox is real-time polymerase chain reaction (PCR), which detects the presence of the monkeypox virus in patient samples. However, in settings where PCR testing is not available, clinicians rely on detailed patient history and clinical presentation to exclude other causes of fever with rashes.
Treatment for monkeypox primarily involves vigilant monitoring of the patient’s condition, supportive care, and management of associated complications. Antiviral therapy may be considered in severe cases or in patients with complications.
Conclusion
The publication of this chapter in Advances in Experimental Medicine and Biology marks a significant milestone in the field of infectious diseases. By providing a comprehensive review of the clinical manifestations of monkeypox, we aim to enhance the understanding of this disease among healthcare professionals and researchers. We extend our gratitude to the dedicated authors, Haneen Abaza, Kuchalambal Agadi, Ayush Anand, and the supervisor, Mohamed Elsaid, for their valuable contributions to this research.
Join us at Medical Research Platform (MRP) as we continue to advance medical knowledge and make a difference in the field of infectious diseases. Together, let’s strive for a healthier future for all.